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Increased GH stimulates the liver to produce IGF-1, which mediates muscle growth, fat loss, tissue repair, and anti-aging benefits

doi: 10.1007/s11356-022-23314-z 110 DorostkarHHaghiralsadatBFHematiMSafariFHassanpourANaghibSMet al

This response is partially mediated by CGRP and/or CSD, and involves oxidative stress, mitochondrial dysfunction, the assembly of NLRP3 inflammasomes, activation of microglia, and the reactivity of astrocytes

Hydrocortisone can restore glycocalyx and improve the 7-day survival rate after brain injury [111]

Elevated IL-6 and IL-8 have previously been associated with FM severity, indicating that multi-marker panels rather than single biomarkers might provide a more robust diagnostic approach

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